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Chapter 400: Animal Research

400.020 Care and Use of Vertebrate Animals as Subjects in Research and Teaching

Executive Guideline No. 22, 2-15-84; Revised 5-20-87.

  1. Purpose -- The policy of the University of Missouri is to foster the humane care and use of vertebrate animals in research and teaching and to adhere to applicable laws, principles, standards, guidelines and policies affecting such care and use.

    This policy and the principles below apply in all situations and activities of the University where vertebrate animals are used in research, instruction or other activities regardless of the source(s) of support. It shall apply equally whether the supporting funds are from outside or from within the University, whether separately budgeted or unbudgeted.

    Responsibility for implementing and administering this policy shall rest wit the Chancellor of each campus (the Vice President for Academic Affairs in the case of UM research programs). In accordance with federal policy and regulations, the Chancellor has responsibility for appointing the Institutional Animal Care and Use Committee. The composition of this committee shall conform to Federal Guidelines.
     
    The committee will:
    1. Review, at least once every six months, the institution's program for humane care and use of animals, using the Guide for the Care and Use of Laboratory Animals and the Animal Welfare Act Regulations and Standards as a basis for evaluation.
    2. Inspect, at least once every six months, the institution's animal facilities (including satellite facilities).
    3. Prepare reports of the IACUC evaluation set forth in the PHS policy and submit the reports to the Chancellor. A more complete list of IACUC regulations and responsibilities is in the PHS policy and 9CRF Parts 1 and 2, Animal Welfare Proposed Rules.

      As part of the campus's program for animal care and use, the Chancellor will provide training or instruction to scientists, animal technicians, and other personnel involved in animal care, treatment, or use in both the practice of animal care and in research and testing methods that minimize the number of animals required to obtain valid results and minimize animal distress.

      The Chancellor will ensure that records of the semiannual reports and recommendations are maintained for at least three years and that, at least once every twelve months, the Institutional Animal Care and Use Committee (IACUC) will report through the Chancellor to Office for Protection from Research Risks (OPRR) on its activities, especially with regard to any changes in the status of the institution's Assurance and other information as required by OPRR.
  2. Principles for the Care and Use of Animals
    1. The Personnel
      1. Experiments involving live, vertebrate animals and the procurement of tissues from living animals for research must be performed by , or under the immediate supervision of, a qualified biological, behavioral or medical scientist.
      2. The housing care and feeding of all experimental animals must be supervised by a properly qualified veterinarian or other scientists competent in such matters.
    2. The Research
      1. The research should be expected to yield results beneficial to society and not be random or unnecessary in nature.
      2. The experiment should be based on knowledge of the disease or problem under study and so designed that the anticipated results will justify its performance.
      3. Statistical analysis, mathematical models or in vitro biological systems should be used when appropriate to complement animal experiments and reduce numbers of animals used.
      4. The experiment should be conducted so as to avoid all unnecessary suffering and injury to animals.
      5. The scientist in charge of the experiment must be prepared to terminate it whenever he or she believes that its continuation may result in unnecessary injury or suffering to animals.
      6. If the experiment or procedure is likely to cause greater discomfort than that attending anesthetization, the animals must first be rendered incapable of perceiving pain and be maintained in that condition until the experiment or procedure is ended. The only exception to these guidelines should be in those cases where anesthetization would defeat the purpose of the procedures. Such procedures must be carefully supervised by the principal investigator or other qualified senior scientists.
      7. Post-experiment care of animals must be such as to minimize discomfort and the consequences of any disability resulting from the experiment in accordance with acceptable practices in veterinary medicine.
      8. If it is necessary to kill an experimental animal, the animal must be killed in a humane manner; i.e., in such a way as to ensure immediate death in accordance with procedures approved by an institutional committee. No animal shall be discarded until after it is dead.
      9. Occupational health procedures outlined in the Personnel Health and Medical Surveillance Program for Animal Care Personnel (See Executive Guideline No. 21) must be followed to minimize the risk of disease transmission between animals and humans.
      10. Safety procedures shall be such as to minimize the risk of exposure of personnel or the unintended risk of animals to hazardous agents.
    3. The Facilities -- Standards for the construction and use of housing, service and surgical facilities should meet those described in the current edition of the publication, Guide for the Care and Use of Laboratory Animals, DHHS, (NIH_ 85-23, or as otherwise required by the U.S. Department of Agriculture regulations established under the terms of the Laboratory Animal Welfare Act (P.L. 89-544) 1966; P.L. 91-579, as amended, 1970; P.L. 94-270; as amended, 1976; P.L. 99-198, as amended 1985), and other laws and regulations as duly promulgated.
    4. Transportation -- Transportation of animals must be in accord with applicable standards and regulations, especially those intended to reduce discomfort, stress to the animals, or spread of disease.
    5. References
      1. Committee on Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. DHHS (NIH) 85-23, Institute of Laboratory Animal Resources, NRC, revised, 1985.
      2. Code of Federal Regulations, Title 9-Animals and Animal Products, Subchapter A-Animal Welfare, January 1985.
      3. Recommendations for Governance and Management of Institutional Animal Resources. Association of American Medical Colleges; Association of American Universities, October 1985.
      4. Rules for Animal Welfare. Federal Register, Vol. 52, No. 61, p. 10292 et seq.
      5. Public Health Service Policy on Humane Care and Use of Laboratory Animals, OPRR, Revised September 1986.

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