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Researchers find fish suffer from effects of BPA

Medaka, or Japanese rice fish, were used in the study to determine reproductive function following exposure to BPA. Photo courtesy of 


Bisphenol A (BPA) is a chemical that is used in a variety of consumer products, such as water bottles, dental composites and resins used to line metal food and beverage containers. Often, aquatic environments such as rivers and streams become reservoirs for contaminants, including BPA. Now, University of Missouri researchers and U.S. Geological Survey (USGS) scientists have determined that fish exposed to endocrine-disrupting chemicals will pass adverse reproductive effects onto their offspring as many as three generations later.

“BPA has been proven to mimic the function of natural hormones in animals and humans. Fish and aquatic organisms often have the greatest exposure to such chemicals during critical periods in their development or even throughout entire life cycles,” said Ramji Bhandari, an assistant research professor of biological sciences at MU and a visiting scientist with the USGS. “This study shows that even though endocrine disruptors may not affect the life of the exposed fish, it may negatively affect future generations.”

Bhandari and fellow scientists Frederick vom Saal, Curators Professor of Biological Sciences in the College of Arts and Science at MU, and Don Tillitt, an adjunct professor of biological sciences and a research toxicologist with the USGS, exposed medaka, or Japanese rice fish, to chemicals that included BPA for one week during embryonic development. The team then studied their offspring through as many as four generations. Subsequent generations were never exposed to the chemicals. No apparent reproductive abnormalities appeared in the first two generations of fish; however, the researchers found that future generations showed a reduced rate of fertilization and increased embryo mortality.

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About this Story

Campus: UMC
Key words: Agriculture, Health, MU Campus, Science,
County: Boone

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