While the U.S. Food and Drug Administration notes “some concern” with the controversial chemical BPA, and many other countries, such as Japan and Canada, have considered BPA product bans, disagreement exists amongst scientists in this field on the effects of BPA in animals and humans. The latest research from the University of Missouri shows that BPA causes male deer mice to become demasculinized and behave more like females in their spatial navigational abilities, leading scientists to conclude that exposure to BPA during human development could be damaging to behavioral and cognitive traits that are unique to each sex and important in reproduction.
“The BPA-exposed deer mice in our study look normal; there is nothing obviously wrong with them. Yet, they are clearly different,” said Cheryl Rosenfeld, associate professor in biomedical sciences in the College of Veterinary Medicine and investigator in the Bond Life Sciences Center. “Females do not want to mate with BPA-exposed male deer mice, and BPA-exposed males perform worse on spatial navigation tasks that assess their ability to find female partners in the wild. This study sets the stage for BPA researchers to examine how BPA might differentially impact the behavioral and cognitive patterns of boys versus girls. Investigators looking for obvious BPA-induced differences, such as chromosome deletions or DNA mutations, could be missing subtle behavioral differences that eventually lead to long-term adverse outcomes, including demasculinization of male behaviors with ensuing decreased reproductive fitness.”